Hey! We live in Burlington which is about middle of the state, triad area.
We have driven at least 4 times, and it has taken us around 10 hrs. Once we made it in 9 1/2 hrs but it was perfect driving conditions, no rain, fog, etc. And this is doing maybe 5-7 over the limit. Believe me, people are still passing us.
We usually stop 3 times, to get fuel, restroom, etc. Our ritual has been to leave around 3am, get a biscuit around 6-7am, stop to fuel, stretch legs, then stop again right before crossing GA, FL border to fuel up one more time.
We take I-85 to Charlotte then I-77 S to I-26 in Columbia SC. I-26 will lead you to I-95 which will lead you to I-4 in Daytona. I-4 will lead to WDW.
Sounds crazy going back towards Charlotte to go to Orlando, but we have driven the I-40, I-95 route once. Thats 45 additional minutes from where we live.
I will be glad to answer any additional ??s if you have any.
We have friends in this area who have driven it at least 30 trips. They told us this route and its not bad at all. We were a little concerned kids wouldnt hold up, but throw some movies in, and they are content.
I will add, leaving that early in the morning, there is method to this madness. By doing this, the traffic or lack of it is a big PLUS! And, you miss business traffic in Jackonville FL and Orlando. This can both be bummers.
One other thing, get an extra day out of WDW by leaving around 5pm or later if it doesnt bother you. We have driven about 3 1/2 hrs back to Kingsland GA, sleep there, then leave the next morn. We have gotten to the point of skipping this if you can share driving with someone. We get home around 3am, leave everything in the car, go to bed, turn the phone off, and get about 6 hrs of sleep.
Sorry for all the extra info. but I know how nervous we were 1st time, but now would rather do this than fly.