HIME is an old style Holiday Inn motel with parking around the perimeter, two stories, outside room entrances, interior courtyard with pool, buildings spread out over large area, rooms have been remodeled.
CSME is much newer, about 6 stories, slightly closer to WDW, walking distance to Old Town, room entrance off interior corridor, nicer pool area.
Beware that both offer suites that are not true suites, IMHO; HIME has "Kidsuites" which is just a partition in a regular hotel motel room, and at CSME most rooms do not have a separate closed off bedroom. Both do offer true suites however, just be careful what you book.
If cost is important, the Holiday Inn Nikki Bird is very similar to HIME but usually can be had for under $50, no real suites however.
CSME is the most attractive and newest of these three.