I am going to be completely honest with you and say that using El Segundo as a home base for your whole trip is probably not the best idea. Burbank is even worse idea. If you do stick to places like these you will spend all of your time driving and in terrible traffic.
To give you some ideas on a good day Santa Barbara is probably 1.5-2 hours one way from El Segundo, and probably a bit more from Burbank. In a dream world Hollywood (most likely the area you will visit most) is about 1 hour from El Segundo, and 30 minutes from Burbank. But with traffic either can take closer to 2 hours one way.
My personal suggestion is to just get hotels as you get to an area, you will be far more relaxed, see more and probably enjoy your trip much more.
Santa Barbara is a beautiful area with lots to do, the ocean, a small zoo, Solvang (a small dutch town) is not far out of town and it has great weather. I would feel pretty good about almost any hotel I stayed in there.
If you plan on doing a whole day in Hollywood, try the Renaissance at Hollywood and Highland, or one of the Universal Hotels (a Sheraton and one I forget the name of the other). The Universal Sheraton I have heard is very nice, is right outside Universal Studios, which even if you don't visit you can go to CityWalk (like DTD but more Studio Focused with Hard Rock and theaters for IMAX, movies and concerts), there is also the redline subway that will take you from Universal City to Hollywood and Highland where you will find the Shopping Complex that houses the Kodak theater, the Walk of Fame, The Chinese Theater and El Capitan/Mickey Malt Shoppe. The subway is really nice cause you won't have to drive and since no one uses it really its very clean haha! (bad LA Driving joke) You can also drive to Beverly Hills from Hollywood as well. Los Angeles itself is really a skip unless you want to go to Staples.
For
Disneyland look at all the great hotels listed in the Disneyland section of the board, there are lots of great ones within very close walking distance from the parks. Or if you want to can splurge and stay at one of the onsite hotels (think Deluxe prices).
If you give us your rough trip schedule maybe we can help you even more. California is a very large state with lots of traffic and it can kill a vacation if you don't plan for it, but with some careful planning and preparedness it won't bug you at all.